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  • Tighten and hydrate skin  

  • Reduce fine lines and wrinkles

  • Reduce hyperpigmentation

  • Improve acne scarring 

  • Stimulate hair growth 

  • Help reduce rosacea 


What are Polynucelotides? 

Polynucleotides are one of the latest innovations in regenerative medicine. They are fragments of DNA that work by increasing the body's generation of fibroblasts, the collagen-forming cells, and therefore increasing the production of collagen. They have a multitude of beneficial effects, including improving skin quality and texture, increasing hydration, reducing hyperpigmentation and acne scarring and stimulating hair growth. Unlike the "skin boosters" such as Profhilo, these work to increase the number and action of fibroblasts, rather than just temporarily increasing their action, thus causing more profound and sustained change in the skin. They have the additional benefits of being used anywhere in the body, including the delicate area around the eye, where they can have transformative effects on the skin quality. 


For best results, 2-4 initial sessions are required (depending on age and initial skin condition), 3-4 weeks apart, and following this 6-monthly treatments are required for maintenance.  

Polynucleotide treatment

Polynucleotides can be injected using either a needle or a cannula (hollow tube). The best results will be achieved using a needle, as the puncture wounds stimulate the skin to start producing collagen, as microneedling does. The treatment effect will be seen quicker as the product is being injected into the desired tissue layer. However, increased bruising and swelling are seen with the use of a needle. Cannula can therefore be helpful when the patient wants to limit the downtime of the treatment.


The product is injected locally, just under the skin, making it extremely safe. With the injection technique, multiple small droplets (micro boluses) will be injected into treatment area. With the cannula technique, threads of product will be distributed under the skin.  

For optimal results, 2-4 initial sessions are required, 3-4 weeks apart, depending on your age and initial skin quality. Following this, repeat sessions are required every 6 months. 

Which areas can be treated with Polynucleotides?

Polynucleotides can be used to treat almost any area of the face or body. Commonly treated areas include:

  • Face

  • Eyes 

  • Neck

  • Body

    • Decolletage​

    • Stomach

    • Arms 

    • Above knees 


The process 

Before treatment 

At your consultation, your area of concern will be assessed and Dr Horlick will recommend a treatment plan based on this. A consent form will be completed and before photos taken. You will now be ready for your treatment.

During treatment 

The treatment area will be cleaned and local anaesthetic cream applied. Once the local anaesthetic cream has taken effect you will be ready commence with the treatment. The product will be distributed throughout the treatment area, using either a cannula or a needle, depending on your treatment goals and desires for your recovery. This will be agreed at your consultation. 

After treatment 

You will be advised of the aftercare instructions and your next appointment booked, if applicable. 


You can expect to see your results anywhere from 2 weeks to 6 weeks after your treatment, depending on the product choice and number of your treatment. Results last for 6 months following your initial treatment package. 

The results

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Proud to offer flexible payments with PLIM. PLIM offer 0% finance, allowing you to split the cost of your aesthetic treatment over 2 or 3 payments, depending on the value.

Sign up to the PLIM website now to find out how much you could borrow, or find out more in clinic. Approval for finance takes as little as 5 minutes. 

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